ABSTRACT
The evaluation of the anti malarial properties of the essential oil extract of Tithoniadiversifolia was carried out using the standard tests suppressive tests in laboratorymice. The Swiss albino mice were infected with rodent malaria parasite(Plasmodium berghei berghei) and were treated with 300mg/kg, 600mg/kg and1200mg/kg dose of the oil extracts. The result showed that the oil extract ofTithonia diversifolia had a very good activity against Plasmodium berghei. Thetest substances were able to reduce the parasitaemia level with a clear significantdifference between the treated groups and the control group, although parasiteswere not totally cleared after termination of treatment.
TABLE OF CONTENTS
Abstract
Tables of contents
List of tables
CHAPTER ONE
1.0 INTRODUCTION
1.1 Medicinal Plant
1.2 Justification of the study
1.3 Aim
1.4 Objective
CHAPTER TWO
2.0 Literature Review
2.1 Description of T. diversifolia
2.2 List of Plates
2.3 Scientific Classification
2.4 Stages of infections
2.5 Malaria parasite
2.7 Pharmacological activities and site of action of T. diversifolia oil extracts against Plasmodium berghei
2.8 Mode of Action
CHAPTER THREE
3.1 Study Area
3.2 Materials and Methods
3.3 Plant materials
3.4 Preparation of Essential oils
3.5 Experimental Animals
3.6 Parasite Species and Preparation of parasite inoculums
3.7 Parasite Inoculation
3.8 4 Day suppressive Test
3.9 Statistical analysis
3.10 Determination of percentage average suppression
CHAPTER FOUR RESULTS
CHAPTER FIVE
DISCUSSION, CONCLUSION AND RECOMMENDATION
5.1 Discussion
5.2 Conclusion
5.3 Recommendation
Reference
Appendix
